Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding

Preprint

24 August 2020

preprint
Published by Research Square Platform LLC

https://doi.org/10.21203/rs.3.rs-30696/v2

Abstract

Background: Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the intracellular role of HMGB1 in hepatocellular steatosis...

Keywords

STRESS
GENE EXPRESSION
TREATMENT
ENERGY EXPENDITURE
HMGB1
INTRACELLULAR
FATTY
HEPATOCELLULAR STEATOSIS
SUGGESTING THAT HEPATOCYTE

Other Versions

Published version: Version Molecular Medicine, 26, preprints