Pervasive transcription constitutes a new level of eukaryotic genome regulation
Open Access
- 31 August 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in EMBO Reports
- Vol. 10 (9), 973-982
- https://doi.org/10.1038/embor.2009.181
Abstract
During the past few years, it has become increasingly evident that the expression of eukaryotic genomes is far more complex than had been previously noted. The idea that the transcriptome is derived exclusively from protein-coding genes and some specific non-coding RNAs-such as snRNAs, snoRNAs, tRNAs or rRNAs-has been swept away by numerous studies indicating that RNA polymerase II can be found at almost any genomic location. Pervasive transcription is widespread and, far from being a futile process, has a crucial role in controlling gene expression and genomic plasticity. Here, we review recent findings that point to cryptic transcription as a fundamental component of the regulation of eukaryotic genomes.This publication has 65 references indexed in Scilit:
- Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiaeGenes & Development, 2009
- Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAsCell, 2007
- RNA Maps Reveal New RNA Classes and a Possible Function for Pervasive TranscriptionScience, 2007
- A role for noncoding transcription in activation of the yeast PHO5 geneProceedings of the National Academy of Sciences of the United States of America, 2007
- Genome-wide transcription and the implications for genomic organizationNature Reviews Genetics, 2007
- Developmentally Regulated piRNA Clusters Implicate MILI in Transposon ControlScience, 2007
- Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in DrosophilaCell, 2007
- Repression of the human dihydrofolate reductase gene by a non-coding interfering transcriptNature, 2007
- Cytoplasmic Decay of Intergenic Transcripts in Saccharomyces cerevisiaeMolecular and Cellular Biology, 2007
- Genome-Wide Distribution of Yeast RNA Polymerase II and Its Control by Sen1 HelicaseMolecular Cell, 2006