CD44s and CD44v6 in Diagnosis and Prognosis of Human Bladder Cancer
- 28 March 2012
- journal article
- Published by Taylor & Francis Ltd in Ultrastructural Pathology
- Vol. 36 (3), 145-152
- https://doi.org/10.3109/01913123.2011.651522
Abstract
The cell adhesion molecules (CAMs) CD44 standard (CD44s) and its variant 6 (CD44v6) are involved in the progression and invasion of human malignancies. However, discrepancies in the prognostic value of CD44s and CD44v6 expression need to be addressed. Aims: To investigate the expression of CD44s and CD44v6 in bladder carcinomas and relate the results to the established prognostic factors. Materials and Methods: 50 bladder carcinoma specimens, 30 cases with transitional cell carcinoma (TCC: 6 bilharzial and 24 nonbilharzial) and 20 cases with squamous cell carcinoma (SCC: 8 bilharzial and 12 nonbilharzial), were included. Immunohistochemical analysis for CD44s and CD44v6 was carried out using avidin–biotin peroxidase method. Results: The level of both CD44s and CD44v6 in TCC was significantly higher in invasive than in preinvasive tumors and normal urothelium (p < .05). A direct association between the percentage of expression of both markers and the grade of TCC (p < .05) was observed. An inverse correlation between CD44s and SCC was seen, where metaplastic urothelium showed higher expression than invasive carcinomas. No association was observed between the expressions of both CD44s and CD44v6 and bilharzial ova, sex and age of the patient, or size of the tumor. Conclusions: The authors report statistically significant correlation between CD44s and CD44v6 expression and increasing grade and stage of TCC. No such correlation with SCC and with bilharzial cystitis, sex and age of the patient, or size of the tumor was documented.Keywords
This publication has 31 references indexed in Scilit:
- Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expressionBJU International, 2010
- Pattern of management of urologic cancer in Saudi ArabiaUrology Annals, 2010
- Incidence analyses of bladder cancer in the Nile delta region of EgyptCancer Epidemiology, 2009
- Upregulated CD44v9 Expression Inhibits the Invasion of Oral Squamous Cell Carcinoma CellsPathobiology, 2004
- CD44: From adhesion molecules to signalling regulatorsNature Reviews Molecular Cell Biology, 2003
- Urinary systemCancer, 1995
- Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigmCell, 1994
- Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular originThe Journal of cell biology, 1993
- A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cellsCell, 1991
- The epidemiology of bladder cancer.A second lookCancer, 1977