Clinicopathologic Evaluation After Resection for Ductal Adenocarcinoma of the Pancreas: A Retrospective, Single-Institution Experience
- 1 April 2003
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pancreas
- Vol. 26 (3), 243-249
- https://doi.org/10.1097/00006676-200304000-00007
Abstract
Between April 1992 and December 2000, 167 patients with pancreatic carcinoma were evaluated and treated in our department. One hundred eight patients (64.7%) with pancreatic carcinoma underwent pancreatectomy. Of these patients, 94 had histologically proven ductal adenocarcinoma. The overall postoperative mortality rate was 3.2% (3 patients), and the morbidity rate was 35.1% (33 patients). The estimated 1-, 2-, 3-, and 5-year survival rates were 43.6%, 28.7%, 21.8%, and 12.9%, respectively. There were only six long-term survivors who survived >5 years after surgery. Institutional experience with 94 consecutive patients with ductal adenocarcinoma who underwent pancreatectomy was reviewed to clarify the influence of 29 prognostic factors (5 host, 17 tumor, and 7 treatment factors). Special reference was made to determine whether these significant factors have an effect on long-term survival. Univariate and multivariate models were used to analyze the effect of prognostic factors on survival. Univariate analysis indicated that blood loss, operative time, postoperative complications, histopathologic lymphatic and venous permeation, lymph node metastasis, conclusive stage, conclusive curability, resection margins, serosal invasion, size of tumor, retroperitoneal invasion, major arterial invasion, and mode of histologic infiltration were associated with significantly longer survival (p b The prognosis after surgical resection of pancreatic carcinoma mostly depends on tumor factors. In this study, it was difficult to identify the determinants of long-term survival in patients with resectable tumors.Keywords
This publication has 18 references indexed in Scilit:
- PANCREATIC CANCER: The Bigger PictureSurgical Clinics of North America, 2001
- Pancreatic cancer: current status of treatment and survival of 16 071 patients diagnosed from 1981–1996, using the Japanese National Pancreatic Cancer DatabaseInternational Journal of Clinical Oncology, 2000
- Are the Results of Pancreatectomy for Pancreatic Cancer Improving?World Journal of Surgery, 1999
- Long-Term Survival After Curative Resection for Pancreatic Ductal AdenocarcinomaAnnals of Surgery, 1996
- Long-Term Survival After Resection for Ductal Adenocarcinoma of the Pancreas Is It Really Improving?Annals of Surgery, 1995
- One Hundred and Forty-Five Consecutive Pancreaticoduodenectomies Without MortalityAnnals of Surgery, 1993
- Factors influencing survival after pancreaticoduodenectomy for pancreatic cancerThe American Journal of Surgery, 1991
- Survival After PancreatoduodenectomyAnnals of Surgery, 1990
- Preoperative Staging and Assessment of Resectability of Pancreatic CancerArchives of Surgery, 1990
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958