Isolated Antibody to Hepatitis B Core Antigen in Human Immunodeficiency Virus Type-1--Infected Individuals
Open Access
- 15 June 2003
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 36 (12), 1602-1605
- https://doi.org/10.1086/375084
Abstract
We screened 651 human immunodeficiency virus (HIV)-1–infected subjects for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B surface antigen (anti-HBs). Of a total of 387 subjects who tested negative for both HBsAg and anti-HBs, 142 underwent further testing for isolated presence of antibody to hepatitis B core antigen (anti-HBc). Of these 142 subjects, 60 (42%) tested positive for anti-HBc (isolated anti-HBc). Individuals coinfected with HIV-1 and hepatitis C virus (HCV) were more likely to have isolated anti-HBc than were subjects with HIV-1 alone (80% vs. 16%, respectively). Our findings suggest that individuals with HIV-1/HCV coinfection for whom there is no serological evidence for hepatitis B virus when screened with HBsAg and anti-HBs will be positive for anti-HBc in >75% of cases. A screening strategy that tests only for HBsAg and anti-HBs in HIV-1–infected patients will miss a large number of individuals with isolated anti-HBc.Keywords
This publication has 8 references indexed in Scilit:
- The evolution of hepatitis B virus serological patterns and the clinical relevance of isolated antibodies to hepatitis B core antigen in HIV infected patientsJournal of Hepatology, 2002
- Serological pattern ?anti-HBc alone?: Report on a workshopJournal of Medical Virology, 2000
- High Frequency of HCV Infection in Individuals with Isolated Antibody to Hepatitis B Core AntigenIntervirology, 2000
- Occult Hepatitis B Virus Infection in Patients with Chronic Hepatitis C Liver DiseaseNew England Journal of Medicine, 1999
- Frequent chronic hepatitis B virus infection in HIV-infected patients positive for antibody to hepatitis B core antigen onlyEuropean Journal of Clinical Microbiology & Infectious Diseases, 1998
- The Significance of Isolated Antibody to Hepatitis B Core Antigen Seropositivity in Patients Infected with Human Immunodeficiency VirusClinical Infectious Diseases, 1996
- Detection of HBs antigen in “anti-HBc alone” positive seraJournal of Hepatology, 1994
- Prevalence of isolated antibody to hepatitis B core antigen in an area endemic for hepatitis B virus infection: Implications in hepatitis B vaccination programsHepatology, 1988