Alcohol and Hepatitis C
- 1 January 2005
- journal article
- research article
- Published by S. Karger AG in Digestive Diseases
- Vol. 23 (3-4), 285-296
- https://doi.org/10.1159/000090176
Abstract
Alcohol use and hepatitis C are prominent risk factors for liver injury and this review offers the current understanding of each factor's effects on liver disease. A Medline database search was preformed for English articles with a focus on alcohol, hepatitis C and liver disease. Article citations were also considered for further applicable articles, and the strongest studies were included in our review. Up to 60% of patients with hepatitis C have a past history of alcohol use. In patients with hepatitis C, chronic alcohol consumption of more than 5 drinks/day increases the rate of liver fibrosis, risk for cirrhosis, hepatocellular carcinoma, and, possibly, death from liver disease. Numerous studies have further found that even moderate amounts of alcohol can be detrimental to hepatitis C patients. The prevalence of hepatitis C is higher in alcoholics with advanced liver disease than in alcoholics without liver disease. Also, recent alcohol use decreases the response rate to interferon treatment. Hepatitis C and alcohol use are often co-occurring risk factors for liver disease, and though their interaction is not clear, it is known that heavy drinking significantly promotes liver disease progression.Keywords
This publication has 70 references indexed in Scilit:
- Alcohol is an important co-factor for both steatosis and fibrosis in Northern Italian patients with chronic hepatitis CJournal of Hepatology, 2004
- Diagnosis and Therapy of Alcoholic Liver DiseaseSeminars in Liver Disease, 2004
- The Natural History of Hepatitis CSeminars in Liver Disease, 2004
- Hepatitis C and AlcoholJournal of Clinical Gastroenterology, 2003
- Role of alcohol in the progression of liver disease caused by hepatitis C virus infectionHepatology, 1998
- Chronic hepatitis C: Effect of alcohol on hepatic activity and viral titreJournal of Hepatology, 1996
- A histopathological study of alcoholics with chronic HCV infection: comparison with chronic hepatitis C and alcoholic liver diseaseLiver International, 1995
- Hepatitis C Virus in Alcoholic Patients with and without Clinically Apparent Liver DiseaseAlcohol: Clinical and Experimental Research, 1995
- Interest of the detection of hepatitis C virus RNA in patients with alcoholic liver disease: Comparison with the HBV statusJournal of Hepatology, 1993
- Serological and histological aspects of hepatitis C virus infection in alcoholic patientsJournal of Hepatology, 1991