Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta‐analysis of randomized controlled trials
- 25 June 2009
- journal article
- review article
- Published by Wiley in Obesity Reviews
- Vol. 10 (4), 475-486
- https://doi.org/10.1111/j.1467-789x.2009.00599.x
Abstract
Observational studies have found that dietary calcium intake is inversely related to body weight and body fat mass. One explanatory mechanism is that dietary calcium increases faecal fat excretion. To examine the effect of calcium from dietary supplements or dairy products on quantitative faecal fat excretion, we performed a systematic review with meta-analysis. We included randomized, controlled trials of calcium (supplements or dairy) in healthy subjects, where faecal fat excretion was measured. Meta-analyses used random-effects models with changes in faecal fat excreted expressed as standardized mean differences, as the studies assessed the same outcome but measured in different ways. An increased calcium intake resulted in increased excretion of faecal fat by a standardized mean difference of 0.99 (95% confidence intervals: 0.63-1.34; P < 0.0001; expected to correspond to similar to 2g day(-1)) with moderate heterogeneity (I-2 = 49.5%) indicating some inconsistency in trial outcomes. However, the dairy trials showed homogeneous outcomes (I-2=0%) indicating consistency among these trials. We estimated that increasing the dairy calcium intake by 1241 mg day(-1) resulted in an increase in faecal fat of 5.2 (1.6-8.8) g day(-1). In conclusion, dietary calcium has the potential to increase faecal fat excretion to an extent that could be relevant for prevention of weight (re-)gain. Long-term studies are required to establish its potential contribution.Keywords
This publication has 51 references indexed in Scilit:
- Effect of dairy calcium on fecal fat excretion: a randomized crossover trialInternational Journal of Obesity, 2008
- Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretionInternational Journal of Obesity, 2005
- Dairy augmentation of total and central fat loss in obese subjectsInternational Journal of Obesity, 2005
- Measuring inconsistency in meta-analysesBMJ, 2003
- Relation between calcium intake and fat oxidation in adult humansInternational Journal of Obesity, 2003
- Meta‐analysis combining parallel and cross‐over clinical trials. I: Continuous outcomesStatistics in Medicine, 2002
- How should meta‐regression analyses be undertaken and interpreted?Statistics in Medicine, 2002
- Quantifying heterogeneity in a meta‐analysisStatistics in Medicine, 2002
- Inhibitory Effect of Calcium (Derived from Eggshell)-Supplemented Chocolate on Absorption of Fat in Human Males.Nippon Eiyo Shokuryo Gakkaishi, 1998
- Significance of Ca-soap formation for calcium absorption in the rat.Gut, 1977