The Diagnostic Applications of Saliva— A Review
Top Cited Papers
Open Access
- 1 March 2002
- journal article
- review article
- Published by SAGE Publications in Critical Reviews in Oral Biology & Medicine
- Vol. 13 (2), 197-212
- https://doi.org/10.1177/154411130201300209
Abstract
This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.Keywords
This publication has 94 references indexed in Scilit:
- A newly developed PCR assay ofH. pylori in gastric biopsy, saliva, and fecesDigestive Diseases and Sciences, 1996
- Shigella-specific IgA in saliva of children with bacillary dysenteryFEMS Microbiology Letters, 1992
- Saliva from cystic fibrosis patients contains an unusual form of epidermal growth factorBiochemical and Biophysical Research Communications, 1990
- The measurement of hormones in saliva: Possibilities and pitfallsJournal of Steroid Biochemistry, 1987
- Diagnosis of pneumococcal pneumonia by detection of antigen in salivaEuropean Journal of Clinical Microbiology & Infectious Diseases, 1986
- Salivary oestradiol and progesterone levels in premenopausal women with breast cancerEuropean Journal of Cancer and Clinical Oncology, 1986
- Infrequency of Isolation of HTLV-III Virus from Saliva in AIDSNew England Journal of Medicine, 1985
- Direct Radioimmunoassay (RIA) of salivary testosterone: correlation with free and total serum testosteroneLife Sciences, 1985
- A Sensitive Direct Enzyme Immunoassay for Cortisol in Plasma and Saliva1)Experimental and Clinical Endocrinology & Diabetes, 1984
- Radioimmunoassay for progesterone in human saliva during the menstrual cycleThe Journal of Steroid Biochemistry and Molecular Biology, 1981