Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue
Open Access
- 11 May 2011
- journal article
- Published by Optica Publishing Group in Biomedical Optics Express
- Vol. 2 (6), 1514-1523
- https://doi.org/10.1364/BOE.2.001514
Abstract
Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specimens acquired before and after incubation with 2-NBDG demonstrated increased fluorescent signal in all of the malignant tissue due to increased 2-NBDG consumption. We demonstrate that 2-NBDG has potential as an optical contrast agent to differentiate cancerous from non-cancerous tissue.Keywords
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