Acetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by silymarin and Terminalia chebula in rats
Open Access
- 1 January 2010
- journal article
- Published by Informatics Publishing Limited in Toxicology International
- Vol. 17 (2), 64-66
- https://doi.org/10.4103/0971-6580.72672
Abstract
Experimental study was conducted to evaluate the hepato- and renoprotective effect of silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) toxicity in rats. Oral administration of APAP @ 500 mg/kg for 1 to 3 days to all the four groups (six rats in each) resulted in significant elevation of serum triglycerides, total cholesterol, blood urea nitrogen, serum creatinine, and aspartate transaminase activity. Post-treatment with silymarin @ 25 mg/kg and T. chebula 125 mg/kg in groups 2 and 3 and their combination to group 4 from day 4 to 14 has significantly reversed the alterations of above said markers and offered better protection. The results of the study enunciated that silymarin and T. chebula exhibit good hepato- and nephro-protection against APAP toxicity.Keywords
This publication has 8 references indexed in Scilit:
- The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damageToxicology, 2008
- Chemomodulatory effects of Terminalia chebula against nickel chloride induced oxidative stress and tumor promotion response in male Wistar ratsJournal of Trace Elements in Medicine and Biology, 2006
- Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic ratsBMC Complementary and Alternative Medicine, 2006
- Antioxidant Effects of Aqueous Extract of Terminalia chebula in Vivo and in VitroBiological & Pharmaceutical Bulletin, 2005
- Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidneyBiochemical Pharmacology, 1992
- Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in miceBiochemical Pharmacology, 1990
- Effects of two bioflavonoids on certain cellular immune reactions in vitro.1990
- THE INDUCTION OF LIVER CELL CANCER BY CHEMICALSPublished by Elsevier BV ,1976