Neonatal hyperbilirubinemia increases intestinal protein permeability and the prevalence of cow's milk protein intolerance
- 15 April 2008
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 97 (6), 751-753
- https://doi.org/10.1111/j.1651-2227.2008.00746.x
Abstract
Bilirubin is a newly discovered modulator of the gut barrier in vitro and in vivo. We studied the effect of bilirubin on the serosal to mucosal intestinal permeability in vivo. We also investigated the prevalence of cow's milk protein intolerance (CMPI) in infants with moderate hyperbilirubinemia versus matched controls.Faecal alpha 1 antitrypsin (a1AT) was used to monitor intestinal protein loss; a large cohort was prospectively followed for 12 months for sign and symptoms of CMPI.Neonates with hyperbilirubinemia had higher stool excretion of a1AT than controls (0.68 +/- 0.28 mg/g vs. 0.25 +/- 0.11 mg/g; p < 0.01). Faecal a1AT correlates with total serum bilirubin (TSB) (r = 0.85; p < 0.01). Also, in the first 12 months of life, formerly hyperbilirubinemic infants had an higher prevalence of CMPI (14/353 vs. 4/339; chi2= 4.018, p = 0.045).Neonatal hyperbilirubinemia increases stool protein loss and is also a mild risk factor for CMPI.Keywords
This publication has 12 references indexed in Scilit:
- New Diseases Derived or Associated with the Tight JunctionArchives of Medical Research, 2007
- Is neonatal phototherapy associated with an increased risk for hospitalized childhood bronchial asthma?Pediatric Allergy and Immunology, 2007
- Effect of hyperbilirubinemia on intestinal permeability in healthy term newbornsActa Paediatrica, 2007
- Intestinal permeability in patients with adverse reactions to foodDigestive and Liver Disease, 2006
- Unconjugated Bilirubin Modulates the Intestinal Epithelial Barrier Function in a Human-Derived In Vitro ModelPediatric Research, 2006
- Primary prevention of atopic dermatitis in breast-fed infants: what is the evidence?The Journal of Pediatrics, 2004
- Indications That Phototherapy Is a Risk Factor for Insulin-Dependent DiabetesDiabetes Care, 2003
- Intestinal Permeation and Gastrointestinal DiseaseJournal of Clinical Gastroenterology, 2002
- Milk allergy/intolerance and atopic dermatitis in infancy and childhoodAllergy, 2001
- Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group.Diabetes Care, 1999