Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4enhancer
Open Access
- 13 November 2013
- journal article
- Published by Springer Science and Business Media LLC in BMC Biology
- Vol. 11 (1), 111
- https://doi.org/10.1186/1741-7007-11-111
Abstract
Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic tools to target and/or manipulate gene expression in a lung mesenchyme-specific manner are not available, which becomes a critical barrier to the study of lung mesenchymal biology and the related pulmonary diseases.Keywords
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