HIV prevalence and phylogenetic characteristics among entry travelers in Xishuangbanna prefecture, Yunnan province, between 2003 and 2012
- 23 December 2016
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 89 (6), 1112-1115
- https://doi.org/10.1002/jmv.24740
Abstract
Xishuangbanna is a popular tourist destination in southern Yunnan Province, bordering with Vietnam and Laos, and Myanmar. There are more than 2 million cross-border travelers annually entering China at two land ports, Daluo and Mohan. To clarify the characteristics of HIV-1 prevalence among entry travelers, a retrospective epidemic investigation was conducted. Between 2003 and 2012, 196 among 91 432 entry travelers were detected to be HIV-1-positive, accounting for infection rate of 0.21%. Eighty-one gag-pol gene sequences were obtained for phylogenetic analyses and subsequent recombination analysis. It was shown that the most prevalent HIV-1 subtype in this population was circulating recombinant form (CRF) 01_AE (42, 51.86%), followed by CRF08_BC (17, 20.99%), CRF07_BC (4, 4.94%), B' (2, 2.47%), C (2, 2.47%), other recombinants (9, 11.11%), and undefined subtype (5, 6.17%). HIV-1 genotype distribution among travelers entering at two land ports is different, CRF01_AE and CRF08_BC accounted for a larger percentage among individuals from Daluo, whereas the proportions of subtype C and undefined URFs were larger among individuals from Mohan. The undefined subtype indicates the occurrence of novel HIV-1 subtype or CRF. This finding is useful for developing of AIDS prevention strategies.Funding Information
- National Natural Science Foundation of China (81460509, 81260248, 31560559)
- National Science and Technology Sport Program of China (2014BAI01B01)
- Yunnan Provincial Education Office Scientific Research Foundation Project (2014J027)
- Applied Basic Research Projects of Yunnan Province (2016FB146)
- Yunnan Province Science and Technology Program (2015FB121)
This publication has 8 references indexed in Scilit:
- Prevalence of human immunodeficiency virus 1 infection in the last decade among entry travelers in Yunnan Province, China.BMC Public Health, 2015
- HIV-1 prevalence and subtype/recombinant distribution among travelers entering China from Vietnam at the HeKou port in the Yunnan province, China, between 2003 and 2012Journal of Medical Virology, 2015
- The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990sAIDS, 2013
- Seroprevalence of HIV, syphilis, and hepatitis C virus in the general population of the Liangshan Prefecture, Sichuan Province, ChinaJournal of Medical Virology, 2011
- Bloodstream Infections among HIV-Infected Outpatients, Southeast AsiaEmerging Infectious Diseases, 2010
- The HIV Epidemic in Yunnan Province, China, 1989-2007JAIDS Journal of Acquired Immune Deficiency Syndromes, 2010
- Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, ChinaTransfusion, 2009
- Molecular Epidemiology of the Heterosexual HIV-1 Transmission in Kunming, Yunnan Province of China Suggests Origin from the Local IDU EpidemicAIDS Research and Human Retroviruses, 2005