A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice
- 31 January 1981
- journal article
- Published by Elsevier BV in European Journal of Cancer (1965)
- Vol. 17 (1), 11-19
- https://doi.org/10.1016/0014-2964(81)90206-1
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistanceEuropean Journal of Cancer (1965), 1980
- 5-Substituted quinazoline antifolatesEuropean Journal of Cancer (1965), 1980
- Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidinesChemico-Biological Interactions, 1977
- Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductaseEuropean Journal of Cancer (1965), 1977
- Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acidsJournal of Medicinal Chemistry, 1977
- Thymidylate synthetase: Studies on the peptide containing covalently bound 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolateBiochemical and Biophysical Research Communications, 1976
- Methotrexate inhibition of CCRF-CEM cultures of human lymphoblastsEuropean Journal of Cancer (1965), 1975
- Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell linesEuropean Journal of Cancer (1965), 1974
- Fluorinated pyrimidines. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotidesBiochemistry, 1974
- Inhibition of thymidylate synthetase by showdomycin and its 5′-phosphateBiochemical and Biophysical Research Communications, 1972