Improved sweat test method for the diagnosis of cystic fibrosis.
Open Access
- 1 October 1984
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 59 (10), 919-922
- https://doi.org/10.1136/adc.59.10.919
Abstract
We describe a new technique of collecting sweat for measurement of osmolality and sodium concentrations. Eighty two subjects were studied--39 controls and 43 patients with cystic fibrosis. Adequate amounts of sweat were obtained in 81 subjects and sweat was analysed for both osmolality and sodium concentrations in 73 subjects. The 34 controls gave sweat osmolality and sodium values ranging from 62 to 196 mmol/kg and 9 to 72 mmol/l respectively. The 39 cystic fibrosis patients gave osmolality values ranging from 220 to 416 mmol/kg and sodium concentrations ranging from 60 to 150 mmol/l. Sweat osmolality alone was determined in eight infants under 50 days of age--four later developed the clinical features of cystic fibrosis and four, in whom cystic fibrosis was suspected, were later excluded. Sweat osmolality values in these two groups ranged from 255 to 345 mmol/kg and 87 to 123 mmol/kg respectively. The simplicity of collecting sweat and the measurement of osmolality offer distinct advantages over techniques previously described.Keywords
This publication has 9 references indexed in Scilit:
- Measurement of Osmolality and Sodium Concentration in Heated-Cup Sweat Collections for the Investigation of Cystic FibrosisAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1983
- Screening for cystic fibrosis by died blood spot trypsin assay.1982
- The sweat test: Sodium and chloride valuesThe Journal of Pediatrics, 1981
- New approach to cystic fibrosis diagnosis by use of an improved sweat-induction/collection system and osmometry.Clinical Chemistry, 1981
- Cooperative Study Comparing Three Methods of Performing Sweat Tests to Diagnose Cystic FibrosisPEDIATRICS, 1980
- DOES THAT CHILD REALLY HAVE CYSTIC FIBROSIS?The Lancet, 1978
- A TEST FOR CONCENTRATION OF ELECTROLYTES IN SWEAT IN CYSTIC FIBROSIS OF THE PANCREAS UTILIZING PILOCARPINE BY IONTOPHORESISPEDIATRICS, 1959
- Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas; clinical significance and relationship to the disease.1953
- ABNORMAL ELECTROLYTE COMPOSITION OF SWEAT IN CYSTIC FIBROSIS OF THE PANCREASPEDIATRICS, 1953