CD23: a multi-functional receptor/ lymphokine?
- 31 May 1989
- journal article
- Published by Elsevier BV in Immunology Today
- Vol. 10 (5), 153-157
- https://doi.org/10.1016/0167-5699(89)90171-0
Abstract
With the demonstration of identity between CD23 and the low affinity IgE Fc receptor (FcϵRII), two previously separate avenues of immunological research have converged into one. Particularly in its guise as ‘Blast-2’ antigen, evidence has been mounting to implicate CD23 as an important molecule in B-cell growth regulation. It might seem pertinent, however, to question a role for an apparently isotype-specific immunoglobulin (Ig) receptor in general B-cell processes. In this article, John Gordon and colleagues attempt to reconcile the two, currently diverse, schools of thought regarding the primary function of CD23 and to provide a structural model that accounts for the biological pleiotropy observed.Keywords
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