Intertwined pathways of programmed cell death in immunity
- 15 June 2010
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 236 (1), 41-53
- https://doi.org/10.1111/j.1600-065x.2010.00918.x
Abstract
Summary: Programmed cell death (PCD) occurs widely in species from every kingdom of life. It has been shown to be an integral aspect of development in multicellular organisms, and it is an essential component of the immune response to infectious agents. An analysis of the phylogenetic origin of PCD now shows that it evolved independently several times, and it is fundamental to basic cellular physiology. Undoubtedly, PCD pervades all life at every scale of analysis. These considerations provide a backdrop for understanding the complexity of intertwined, but independent, cell death programs that operate within the immune system. In particular, the contributions of apoptosis, autophagy, and necrosis in the resolution of an immune response are considered.Keywords
This publication has 152 references indexed in Scilit:
- Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial ApoptosisMolecular Cell, 2009
- Autophagy, Immunity, and Microbial AdaptationsCell Host & Microbe, 2009
- Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced InflammationCell, 2009
- Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-αCell, 2009
- What is the mitochondrial permeability transition pore?Journal of Molecular and Cellular Cardiology, 2009
- Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of AutoimmunityImmunity, 2008
- Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of AutoimmunityImmunity, 2007
- Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMOMolecular Cell, 2006
- Cell DeathCell, 2004
- Anoikis mechanismsCurrent Opinion in Cell Biology, 2001