Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
Open Access
- 1 June 2012
- journal article
- Published by Taylor & Francis Ltd in International Journal of Nanomedicine
- Vol. 7, 2829-2832
- https://doi.org/10.2147/IJN.S31810
Abstract
This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold chloride or gold acetate complexes of a bis(imino)acenaphthene (BIAN)-supported NHC with aqueous solutions of polyvinyl alcohol (PVA). The products were characterized by scanning-electron microscopy, which revealed that nanofibers in the range of 250–300 nm had been produced. The biological activities of the nanofiber composites were tested against two Gram-positive bacteria, six Gram-negative bacteria, and two fungal strains. No activity was evident against the fungal strains. However, the gold chloride complex was found to be active against all the Gram-positive pathogens and one of the Gram-negative pathogens. It was also found that the activity of the produced nanofibers was localized and that no release of the bioactive compound from the nanofibers was evident. The demonstrated antimicrobial activities of these novel nanofiber composites render them potentially useful as wound dressings.Keywords
This publication has 9 references indexed in Scilit:
- Antimicrobial Properties of Some Bis(Iminoacenaphthene (BIAN)-Supported N-Heterocyclic Carbene Complexes of Silver and GoldMolecules, 2011
- Synthesis and coordination compounds of a bis(imino)acenaphthene (BIAN)-supported N-heterocyclic carbeneDalton Transactions, 2010
- Recent developments in the coordination chemistry of bis(imino)acenaphthene (BIAN) ligands with s- and p-block elementsDalton Transactions, 2008
- Electrospinning: A Fascinating Method for the Preparation of Ultrathin FibersAngewandte Chemie-International Edition, 2007
- Silver(I)−Imidazole Cyclophane gem-Diol Complexes Encapsulated by Electrospun Tecophilic Nanofibers: Formation of Nanosilver Particles and Antimicrobial ActivityJournal of the American Chemical Society, 2005
- PVA hydrogel sheet macroencapsulation for the bioartificial pancreasBiomaterials, 2004
- Novel biodegradable electrospun membrane: scaffold for tissue engineeringBiomaterials, 2003
- Change in electrophoretic mobility of PC12 cells after culturing on PVA membranes modified with different diaminesJournal of Biomedical Materials Research Part A, 2003
- Attachment and growth of cultured fibroblast cells on PVA/chitosan-blended hydrogelsJournal of Biomedical Materials Research, 1998