Overexpression of CHKA contributes to tumor progression and metastasis and predicts poor prognosis in colorectal carcinoma
Open Access
- 20 August 2016
- journal article
- research article
- Published by Impact Journals, LLC in Oncotarget
- Vol. 7 (41), 66660-66678
- https://doi.org/10.18632/oncotarget.11433
Abstract
// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Liang Hu1, 6, *, Ruo-Yu Wang2, *, Jian Cai3, *, Dan Feng4, *, Guang-Zhen Yang5, Qing-Guo Xu2, Yan-Xia Zhai1, Yu Zhang1, Wei-Ping Zhou2, Qing-Ping Cai6 1Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China 2The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China 3Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 4Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai, China 5Department of Clinical Laboratory, 150th Hospital of PLA, Luoyang, China 6Department of Gastrointestine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China *These authors contributed equally to this work Correspondence to: Liang Hu, email: lianghudoc@163.com Qing-Ping Cai, email: caiqingpingwcwk@163.com Keywords: CHKA, colorectal carcinoma, progression, prognosis, biomarker Received: January 06, 2016 Accepted: August 13, 2016 Published: August 20, 2016Keywords
This publication has 64 references indexed in Scilit:
- Combined 5-FU and ChoKα Inhibitors as a New Alternative Therapy of Colorectal Cancer: Evidence in Human Tumor-Derived Cell Lines and Mouse XenograftsPLOS ONE, 2013
- Functional interactions between Choline kinase α, epidermal growth factor receptor and c-Src in breast cancer cell proliferationOncogene, 2011
- Hepatitis B Virus X Protein Enhances Cisplatin-Induced Hepatotoxicity via a Mechanism Involving Degradation of Mcl-1Journal of Virology, 2011
- A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signalingOncogene, 2011
- Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cellsNMR in Biomedicine, 2010
- Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer CellsCancer Research, 2010
- A critical role for choline kinase-α in the aggressiveness of bladder carcinomasOncogene, 2009
- Noninvasive Detection of Lentiviral-Mediated Choline Kinase Targeting in a Human Breast Cancer XenograftCancer Research, 2009
- Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cellsMolecular Cancer, 2009
- Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathwayMolecular Cancer, 2009