Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters
- 31 August 2009
- journal article
- research article
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 30 (7), 345-355
- https://doi.org/10.1002/bdd.680
Abstract
The nuclear transcription factor E2-related factor 2 (Nrf2) has been shown to play pivotal roles in preventing xenobiotic-related toxicity and carcinogen-induced carcinogenesis. These protective roles of Nrf2 have been attributed in part to its involvement in the induction of Phase II drug conjugation/detoxification enzymes as well as antioxidant enzymes through the Nrf2-antioxidant response element (ARE) signaling pathways. This review summarizes the current research status of the identification of Nrf2-regulated drug metabolism enzymes (DMEs), especially Phase II DMEs, and Phase III drug transporters. In addition, the molecular mechanisms underlying the coordinated regulation of Phase II DMEs and Phase III transporters will also be discussed based on findings published in the literature. Copyright © 2009 John Wiley & Sons, Ltd.Keywords
This publication has 58 references indexed in Scilit:
- Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathwayHepatology, 2007
- Regulation ofCYP2A5Gene by the Transcription Factor Nuclear Factor (Erythroid-Derived 2)-Like 2Drug Metabolism and Disposition, 2007
- Role of Nrf2 in the regulation of the Mrp2 (ABCC2) geneBiochemical Journal, 2006
- Regulation of Nrf2, NF-κB, and AP-1 Signaling Pathways by Chemopreventive AgentsAntioxidants and Redox Signaling, 2005
- REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATPS) IN LIVER BY PROTOTYPICAL MICROSOMAL ENZYME INDUCERS THAT ACTIVATE DISTINCT TRANSCRIPTION FACTOR PATHWAYSDrug Metabolism and Disposition, 2005
- Regulation of Nrf2 Transactivation Domain ActivityOnline Journal of Public Health Informatics, 2004
- Cancer chemoprevention with dietary phytochemicalsNature Reviews Cancer, 2003
- Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 PromoterMolecular and Cellular Biology, 2002
- An Alternative Promoter Contributes to Tissue- and Inducer-Specific Expression of the Rat UDP-Glucuronosyltransferase 1A6 GeneToxicology and Applied Pharmacology, 2001
- Role of cytochrome P1 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutantsCarcinogenesis: Integrative Cancer Research, 1987