Parole terms for a killer
- 1 August 2010
- journal article
- Published by Taylor & Francis Ltd in Cell Cycle
- Vol. 9 (15), 3012-3017
- https://doi.org/10.4161/cc.9.15.12335
Abstract
In a series of discoveries over the preceding decade, a number of laboratories have unequivocally established that apoptotic proteins and pathways are well conserved cell fate determinants, which act independent of a cell death response. Within this context, the role for apoptotic proteins in the induction of cell differentiation has been widely documented. Despite these discoveries, little information has been forthcoming regarding a conserved mechanism by which apoptotic proteins achieve this non-death outcome. In the following discussion, we will explore the premise that the penultimate step in apoptosis, genome wide DNA damage/strand breaks act as a conserved genomic reprogramming event necessary for cell differentiation (Larsen et al., Proc Natl Acad Sci USA 2010; 107 (9):4230-5). Moreover, we hypothesis that directed DNA damage, as mediated by known apoptotic proteins, may participate in numerous forms of regulated gene expression.Keywords
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