Tetrabenazine as antichorea therapy in Huntington disease: A randomized controlled trial

Abstract

The only action ascribed to TBZ in achieving the clinical benefit was inhibiting presynaptic vesicular monoamine transporters to block amine reuptake and secondarily decrease dopamine levels. Although this mechanism is clearly established, TBZ is also functionally effective as a dopamine receptor antagonist based on a large body of rigorous literature. This additional mechanism could well contribute to the clinical benefit observed and possibly explain some unexpected results.