7‐Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures
- 1 December 1992
- journal article
- Published by Wiley in European Journal of Neuroscience
- Vol. 4 (12), 1411-1415
- https://doi.org/10.1111/j.1460-9568.1992.tb00167.x
Abstract
Prior studies with in vitro model systems have suggested that at least part of the neurological manifestations of AIDS may stem from neuronal injury involving the HIV-1 coat protein gp120. This form of neuronal damage is most probably mediated indirectly by a complex set of cellular interactions among macrophages, astrocytes, and neurons, resulting in a final common pathway of overstimulation of N-methyl-d-aspartate (NMDA) receptors. We studied the neuroprotective effect from gp120-induced neuronal injury of an antagonist of the glycine site of the NMDA receptor, 7-chlorokynurenate. In identified rat retinal ganglion cells in culture, we found that 50 microM 7-chlorokynurenate significantly abrogated the injury engendered by 20 pM gp120. Addition of 300 microM exogenous glycine prevented this protective effect of 50 microM 7-chlorokynurenate. These data suggest that glycine site antagonists of the NMDA receptor may have therapeutic potential for ameliorating neuronal damage associated with gp120.Keywords
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