Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean
- 2 June 2010
- journal article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 26 (13), 10425-10428
- https://doi.org/10.1021/la101542m
Abstract
A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to inhibit the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.Keywords
This publication has 29 references indexed in Scilit:
- Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formationBiomaterials, 2009
- Pursuing “Zero” Protein Adsorption of Poly(carboxybetaine) from Undiluted Blood Serum and PlasmaLangmuir, 2009
- Film Thickness Dependence of Protein Adsorption from Blood Serum and Plasma onto Poly(sulfobetaine)-Grafted SurfacesLangmuir, 2008
- Zwitterionic Polymers Exhibiting High Resistance to Nonspecific Protein Adsorption from Human Serum and PlasmaBiomacromolecules, 2008
- Inhibition of bacterial adhesion and biofilm formation on zwitterionic surfacesBiomaterials, 2007
- Coating of a surface with 2-methacryloyloxyethyl phosphorylcholine (MPC) co-polymer significantly reduces retention of human pathogenic microorganismsFEMS Microbiology Letters, 2005
- Preparation and investigation of antibacterial carbohydrate-based surfacesCarbohydrate Research, 2002
- Implant infections: a haven for opportunistic bacteriaJournal of Hospital Infection, 2001
- Phosphorylcholine-based polymers and their use in the prevention of biofoulingColloids and Surfaces B: Biointerfaces, 2000
- New biomaterials through surface segregation phenomenon: New quaternary ammonium compounds as antibacterial agentsJournal of Biomaterials Science, Polymer Edition, 1994