Animal model of systemic carnitine deficiency: Analysis in C3H-H-2° strain of mouse associated with juvenile visceral steatosis
- 1 February 1991
- journal article
- Published by Elsevier BV in Biochemical and Biophysical Research Communications
- Vol. 174 (3), 1090-1094
- https://doi.org/10.1016/0006-291x(91)91532-h
Abstract
We analyzed carnitine profiles in C3H-H-2° strain of mouse associated with fatty liver, hyperammonemia and hypoglycemia (Koizumi et al., 1988). Carnitine levels in serum, liver and muscle of mouse with fatty liver were markedly decreased in comparison with those of control mouse (littermates without fatty liver). This is a useful animal model to analyze the role of carnitine in lipid, amino acid and carbohydrate metabolism.Keywords
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