A Key Role of the Basal Ganglia in Pain and Analgesia - Insights Gained through Human Functional Imaging
Top Cited Papers
Open Access
- 1 January 2010
- journal article
- review article
- Published by SAGE Publications in Molecular Pain
- Vol. 6, 27
- https://doi.org/10.1186/1744-8069-6-27
Abstract
The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these structures in pain processing. Recently neuroimaging has added important information on BG activation in conditions of acute pain, chronic pain and as a result of drug effects. Our current understanding of alterations in cortical and sub-cortical regions in pain suggests that the BG are uniquely involved in thalamo-cortico-BG loops to integrate many aspects of pain. These include the integration of motor, emotional, autonomic and cognitive responses to pain.Keywords
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