Prevalence of Diabetes and Impaired Glucose Tolerance in 64-Year-Old Swedish Women
- 1 February 2006
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 29 (2), 363-367
- https://doi.org/10.2337/diacare.29.02.06.dc05-1229
Abstract
OBJECTIVE—The purpose of this study was to describe the prevalence of diabetes and impaired glucose tolerance (IGT) in middle-aged women and to examine the variability and practical use of the oral glucose tolerance test (OGTT) in the screening for IGT and diabetes. RESEARCH DESIGN AND METHODS—All 64-year-old women living in Göteborg, Sweden, were invited to take part in a screening examination (n = 4,856). Of these, 82% (n = 3,998) responded and 53% (n = 2,595) participated and underwent anthropometric measurements and a 75-g standardized OGTT that was repeated within 2 weeks in those not showing normal glucose tolerance (NGT). RESULTS—The prevalences of known and new diabetes, IGT at both OGTTs, and impaired fasting glucose were 4.7, 4.8, 14.4, and 6.4%, respectively. Half of the women with diabetes were previously undiagnosed, and 37% of the diagnoses were based on OGTT and diabetes 2-h values at both or one of the two examinations. Women with IGT at both OGTTs, in comparison with those with one impaired and one normal OGTT, had higher BMI, waist girth, and blood pressure. More than 40% of the women showed impaired glucose metabolism. CONCLUSIONS—Among these women, the prevalence of undetected diabetes was high and repeated OGTTs were needed to identify and not misclassify a considerable proportion of patients. The degree of glucose tolerance impairment and the number of abnormal OGTTs were directly associated with occurrence of components of the metabolic syndrome.Keywords
This publication has 24 references indexed in Scilit:
- Performance of Screening Questionnaires and Risk Scores for Undiagnosed DiabetesArchives of Internal Medicine, 2005
- Characterisation of subjects with early abnormalities of glucose tolerance in the Stockholm Diabetes Prevention Programme: the impact of sex and type 2 diabetes heredityDiabetologia, 2004
- Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminThe New England Journal of Medicine, 2002
- Diagnosing diabetes mellitus - do we need new criteria?Diabetologia, 1997
- Determining Diabetes Prevalence: a Rational Basis for the Use of Fasting Plasma Glucose Concentrations?Diabetic Medicine, 1990
- The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913Diabetes, 1985
- The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913Diabetes, 1985
- Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed Type 2 (non-insulin-dependent) diabetic subjectsDiabetologia, 1985
- Photocoagulation therapy of proliferative retinopathy in young onset Type 1 (insulin-dependent) diabetesDiabetologia, 1982
- The Bedford Survey: Ten year mortality rates in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabeticsDiabetologia, 1982