NADPH Oxidases of the Brain: Distribution, Regulation, and Function
- 1 September 2006
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 8 (9-10), 1583-1596
- https://doi.org/10.1089/ars.2006.8.1583
Abstract
The NADPH oxidase is a multi-subunit enzyme that catalyzes the reduction of molecular oxygen to form superoxide (O(2)(-)). While classically linked to the respiratory burst in neutrophils, recent evidence now shows that O(2)(-) (and associated reactive oxygen species, ROS) generated by NADPH oxidase in nonphagocytic cells serves myriad functions in health and disease. An entire new family of NADPH Oxidase (Nox) homologues has emerged, which vary widely in cell and tissue distribution, as well as in function and regulation. A major concept in redox signaling is that while NADPH oxidase-derived ROS are necessary for normal cellular function, excessive oxidative stress can contribute to pathological disease. This certainly is true in the central nervous system (CNS), where normal NADPH oxidase function appears to be required for processes such as neuronal signaling, memory, and central cardiovascular homeostasis, but overproduction of ROS contributes to neurotoxicity, neurodegeneration, and cardiovascular diseases. Despite implications of NADPH oxidase in normal and pathological CNS processes, still relatively little is known about the mechanisms involved. This paper summarizes the evidence for NADPH oxidase distribution, regulation, and function in the CNS, emphasizing the diversity of Nox isoforms and their new and emerging role in neuro-cardiovascular function. In addition, perspectives for future research and novel therapeutic targets are offered.Keywords
This publication has 117 references indexed in Scilit:
- NADPH Oxidase–Derived Superoxide Anion Mediates Angiotensin II–Induced Pressor Effect via Activation of p38 Mitogen–Activated Protein Kinase in the Rostral Ventrolateral MedullaCirculation Research, 2005
- Simvastatin Therapy Normalizes Sympathetic Neural Control in Experimental Heart FailureCirculation, 2005
- Superoxide Mediates Angiotensin II–Induced Influx of Extracellular Calcium in Neural CellsHypertension, 2005
- Activation of NADPH oxidase and extracellular superoxide production in seizure‐induced hippocampal damageJournal of Neurochemistry, 2004
- Angiotensin II Impairs Neurovascular Coupling in Neocortex Through NADPH Oxidase–Derived RadicalsCirculation Research, 2004
- Reactive oxygen species stimulate central and peripheral sympathetic nervous system activityAmerican Journal of Physiology-Heart and Circulatory Physiology, 2004
- RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxiaNature Medicine, 2004
- Increased Reactive Oxygen Species in Rostral Ventrolateral Medulla Contribute to Neural Mechanisms of Hypertension in Stroke-Prone Spontaneously Hypertensive RatsCirculation, 2004
- Reactive Oxygen Species in the Cerebral CirculationDrugs, 2004
- Activation of NADPH Oxidase in Alzheimer's Disease BrainsBiochemical and Biophysical Research Communications, 2000