Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways
Open Access
- 1 January 2011
- journal article
- review article
- Published by Hindawi Limited in Gastroenterology Research and Practice
- Vol. 2011, 1-16
- https://doi.org/10.1155/2011/971938
Abstract
There is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have been explored as a potential treatment for IBD and other diseases. The mechanism of action for probiotics has yet to be fully elucidated. This paper discusses novel mechanisms of action for probiotics involving anti-inflammatory signaling pathways. We highlight recent progress in probiotics and nuclear receptor signaling, such as peroxisome-proliferator-activated receptor gamma (PPAR) and vitamin D receptor (VDR). We also discuss future areas of investigation.
Keywords
Funding Information
- National Institutes of Health (DK075386-0251, R03DK089010-01, N09G-279)
This publication has 134 references indexed in Scilit:
- Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL#3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled StudyThe American Journal of Gastroenterology, 2010
- Enteric dysbiosis associated with a mouse model of alcoholic liver diseaseJournal of Hepatology, 2010
- Effect of live Lactobacillus plantarum L2 on TNF-α-induced MCP-1 production in Caco-2 cellsInternational Journal of Food Microbiology, 2010
- Homeostasis and Inflammation in the IntestineCell, 2010
- Treating irritable bowel syndrome with probiotics: the evidenceProceedings of the Nutrition Society, 2010
- Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunityJournal of Molecular Medicine, 2010
- Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generationFree Radical Biology & Medicine, 2009
- Bacteria-free solution derived from lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome functionInflammatory Bowel Diseases, 2009
- Human gut microbes associated with obesityNature, 2006
- Antimicrobial peptides of multicellular organismsNature, 2002