Evidence for the pulmonary origin of alveolar macrophages
- 1 November 1982
- journal article
- Published by Wiley in Cell Proliferation
- Vol. 15 (6), 577-584
- https://doi.org/10.1111/j.1365-2184.1982.tb01064.x
Abstract
This paper supports the hypothesis that some form of pulmonary alveolar macrophage (PAM) production occurs within the lung in the normal steady state. The study involved monitoring the change in number of labelled PAMs following two modes of irradiation--the first with the thorax being irradiated and the rest of the mouse shielded, the second with the thorax shielded and the body irradiated. Also measurements of monocyte and PAM numbers after a single bone marrow irradiation were carried out. Finally, the labelling indices of monocytes in both control and thorax irradiated mice were measured. Both the number of monocytes and PAMs, along with the labelling indices of monocytes and PAMs after irradiation, indicate the independence of PAMs from a monocyte precursor population, and also provide evidence for a pulmonary origin of PAMs.Keywords
This publication has 9 references indexed in Scilit:
- Origin and kinetics of pulmonary macrophages during an inflammatory reaction induced by intravenous administration of heat-killed bacillus Calmette-Guérin.The Journal of Experimental Medicine, 1981
- Origin, Kinetics, and characteristics of pulmonary macrophages in the normal steady state.The Journal of Experimental Medicine, 1979
- Macrophage proliferation in vitro induced by exudatesNature, 1975
- The Pulmonary Macrophage in Acute LeukemiaNew England Journal of Medicine, 1974
- Proliferative Capacity of Human Alveolar MacrophageNature, 1974
- Growth of Pulmonary Alveolar Macrophages in vitroNature, 1973
- Cytodynamics in the respiratory tract of the rat.Thorax, 1966
- Cell Turnover in the Respiratory TractDiseases of the Chest, 1964
- Cell Turnover in Pulmonary TissuesNature, 1962