Immunologic mechanisms of cutaneous drug reactions

Abstract

Idiosyncratic reactions (type B) are a major complication of drug therapy, because they are related to both the drug and to individual factors in the host. In comparison with other organs, the skin is quite frequently a target of allergic reactions, which are mainly elicited by small molecular weight compounds. This is the case in allergic contact dermatitis as well as in drug allergic reactions. In contrast to allergic contact dermatitis however, drug-induced hypersensitivity reactions of the skin have enormous variability with regard to their pathophysiological pathways, clinical signs of symptoms, severity, and the drugs which can elicit these reactions. Allergic reactions are mediated either by specific antibodies or a cellular immunocompetent immune response. About 25% to 30% of type B reactions are estimated to be allergic drug reactions, which are classified by the latency period between the ingestion of the responsible allergen and the onset of clinical symptoms. Studying the mechanisms of these hypersensitivity reactions improves our understanding of these diseases in general, and shows the importance of the skin as a signaling organ in these reactions.