The classic EDCs, phthalate esters and organochlorines, in relation to abnormal sperm quality: a systematic review with meta-analysis
Open Access
- 25 January 2016
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 6 (1), 19982
- https://doi.org/10.1038/srep19982
Abstract
The association between endocrine disrupting chemicals (EDCs) and human sperm quality is controversial due to the inconsistent literature findings, therefore, a systematic review with meta-analysis was performed. Through the literature search and selection based on inclusion criteria, a total of 9 studies (7 cross-sectional, 1 case-control and 1 pilot study) were analyzed for classic EDCs (5 studies for phthalate esters and 4 studies for organochlorines). Funnel plots revealed a symmetrical distribution with no evidence of publication bias (Begg’s test: intercept = 0.40; p = 0.692). The summary odds ratios (OR) of human sperm quality associated with the classic EDCs was 1.67 (95% CI: 1.31–2.02). After stratification by specific chemical class, consistent increases in the risk of abnormal sperm quality were found in phthalate ester group (OR = 1.52; 95% CI: 1.09–1.95) and organochlorine group (OR = 1.98; 95% CI: 1.34–2.62). Additionally, identification of official data and a comprehensive review of the mechanisms were performed and better elucidated the increased risk of these classic EDCs on abnormal sperm quality. The present systematic review and meta-analysis helps to identify the impact of classic EDCs on human sperm quality. However, it still highlights the need for additional epidemiological studies in a larger variety of geographic locations.This publication has 77 references indexed in Scilit:
- Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenylsReproductive Toxicology, 2012
- Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of ActionJournal of Environmental and Public Health, 2012
- Phthalates and other additives in plastics: human exposure and associated health outcomesPhilosophical Transactions B, 2009
- Endocrine-Disrupting Chemicals: An Endocrine Society Scientific StatementEndocrine Reviews, 2009
- Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell ApoptosisToxicological Sciences, 2008
- Adverse trends in male reproductive health: we may have reached a crucial ‘tipping point’International Journal of Andrology, 2008
- Impaired Semen Quality Associated With Environmental DDT Exposure in Young Men Living in a Malaria Area in the Limpopo Province, South AfricaJournal of Andrology, 2007
- Semen quality in fertile US men in relation to geographical area and pesticide exposureInternational Journal of Andrology, 2006
- Reduced Seminal Parameters Associated With Environmental DDT Exposure andp,p′‐DDE Concentrations in Men in Chiapas, Mexico: A Cross‐Sectional StudyJournal of Andrology, 2006
- Quantifying heterogeneity in a meta-analysisStatistics in Medicine, 2002