Maternal vitamin D deficiency, ethnicity and gestational diabetes
- 28 June 2008
- journal article
- Published by Wiley in Diabetic Medicine
- Vol. 25 (6), 678-684
- https://doi.org/10.1111/j.1464-5491.2008.02422.x
Abstract
Aims Vitamin D deficiency has been linked to impaired glucose metabolism. We determined whether serum 25-hydroxyvitamin D (25OHD) is associated with glucose metabolism in pregnant women and the effect of ethnicity on this relationship. Methods We analysed serum 25OHD concentrations in 307 pregnant women attending a metropolitan obstetric clinic between October 2003 and May 2005. Measurements from 264 of the women were taken at the time of glucose tolerance testing at mid-gestation, a population therefore at increased risk for gestational diabetes. Pearson correlation analysis was used to test for univariate linear relationships between the natural log of serum 25OHD (ln-25OHD) and other variables. Multiple regression analysis was used to adjust for confounding factors. Results Mean serum 25OHD concentration was 53.8 ± 23.9 nmol/l (sd). Ln-25OHD was negatively correlated with serum parathyroid hormone as expected (r −0.24, confidence intervals −0.35 to −0.12). Ln-25OHD was also negatively correlated with fasting plasma glucose (r−0.20, −0.31 to −0.08), fasting insulin (r −0.20, −0.31 to −0.08) and insulin resistance as calculated by homeostatis model assessment (r −0.21, −0.32 to −0.09). The association between fasting glucose and log-transformed 25OHD concentration was of borderline significance after accounting for ethnicity, age and body mass index in multivariate analyses (−0.13, −0.26 to 0.01). The odds ratio of gestational diabetes in women with 25OHD < 50 nmol/l did not reach statistical significance (1.92, 95% confidence interval 0.89–4.17). Conclusions Maternal 25OHD concentrations are inversely related to fasting glucose, although further studies are required to establish whether this is independent of the effects of ethnic background.Keywords
This publication has 40 references indexed in Scilit:
- Correlation between vitamin D3 deficiency and insulin resistance in pregnancyDiabetes/Metabolism Research and Reviews, 2007
- Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy OutcomesThe New England Journal of Medicine, 2005
- Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal womenClinical Endocrinology, 2005
- Vitamin D: A millenium perspectiveJournal of Cellular Biochemistry, 2003
- Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’?British Journal of Nutrition, 1998
- Serum 25‐hydroxyvitamin D3 is related to physical activity and ethnicity but not obesity in a multicultural workforceAustralian and New Zealand Journal of Medicine, 1995
- Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitusDiabetes Research and Clinical Practice, 1995
- 25-Hydroxyvitamin D and Total Calcium: Extraordinarily Low Plasma Concentrations in Saudi Mothers and Their NeonatesPediatric Research, 1984
- INCREASED SKIN PIGMENT REDUCES THE CAPACITY OF SKIN TO SYNTHESISE VITAMIN D3The Lancet, 1982
- Vitamin D Deficiency Inhibits Pancreatic Secretion of InsulinScience, 1980