Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (7), 2573-2576
- https://doi.org/10.1128/aac.01633-05
Abstract
Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.Keywords
This publication has 18 references indexed in Scilit:
- Resistance to ceftazidime is associated with a S220Y substitution in the omega loop of the AmpC β-lactamase of a Serratia marcescens clinical isolateJournal of Antimicrobial Chemotherapy, 2005
- Molecular Characterization of Cefoxitin-Resistant Escherichia coli from Canadian HospitalsAntimicrobial Agents and Chemotherapy, 2005
- AmpC β-Lactamase in an Escherichia coli Clinical Isolate Confers Resistance to Expanded-Spectrum CephalosporinsAntimicrobial Agents and Chemotherapy, 2004
- Inhibitor-Sensitive AmpC β-Lactamase Variant Produced by an Escherichia coli Clinical Isolate Resistant to Oxyiminocephalosporins and CephamycinsAntimicrobial Agents and Chemotherapy, 2004
- Resistance to Cefepime and Cefpirome Due to a 4-Amino-Acid Deletion in the Chromosome-Encoded AmpC β-Lactamase of a Serratia marcescens Clinical IsolateAntimicrobial Agents and Chemotherapy, 2004
- AmpC -lactamases: what do we need to know for the future?Journal of Antimicrobial Chemotherapy, 2003
- Plasmid-Determined AmpC-Type β-LactamasesAntimicrobial Agents and Chemotherapy, 2002
- Mutation in Serratia marcescens AmpC β-Lactamase Producing High-Level Resistance to Ceftazidime and CefpiromeAntimicrobial Agents and Chemotherapy, 2001
- Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of anEnterobacter cloacaeclinical isolateFEMS Microbiology Letters, 2001
- Structure of the Extended-Spectrum Class C β-Lactamase of Enterobacter cloacae GC1, a Natural Mutant with a Tandem Tripeptide Insertion,Biochemistry, 1999