Regulating B‐cell activation and survival in response to TLR signals
- 17 July 2007
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 85 (6), 471-475
- https://doi.org/10.1038/sj.icb.7100097
Abstract
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B-cell receptor in a specific antigen-defined manner, or through Toll-like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nuclear factor B pathway controls and coordinates B-cell division and survival following TLR4 engagement.Keywords
Funding Information
- National Health and Medical Research
- Leukemia and Lymphomas Society
This publication has 27 references indexed in Scilit:
- The Bcl-2 apoptotic switch in cancer development and therapyOncogene, 2007
- Signaling to NF-κBGenes & Development, 2004
- Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel−/− B cellsOncogene, 2003
- Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic functionOncogene, 2003
- Toll-Like Receptor Signaling PathwaysScience, 2003
- Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, BimJournal of Biological Chemistry, 2003
- NF-κB1/p105 Regulates Lipopolysaccharide-Stimulated MAP Kinase Signaling by Governing the Stability and Function of the Tpl2 KinaseMolecular Cell, 2003
- The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B CellsThe Journal of Experimental Medicine, 2000
- The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activationCurrent Opinion in Immunology, 1998
- Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte FunctionScience, 1997