Progression of cortical thinning in early Parkinson's disease
- 2 November 2012
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 27 (14), 1746-1753
- https://doi.org/10.1002/mds.25240
Abstract
The aim of this study was to investigate the progression of cortical thinning and gray‐matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow‐up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early‐PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel‐based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over‐time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over‐time changes in cognitive functioning. In early‐PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD‐degenerative process. © 2012 Movement Disorder SocietyKeywords
This publication has 58 references indexed in Scilit:
- Focal cortical and subcortical atrophy in early Parkinson's diseaseMovement Disorders, 2010
- Regional Brain Stem Atrophy in Idiopathic Parkinson's Disease Detected by Anatomical MRIPLOS ONE, 2009
- Cognitive function in early Parkinson’s disease: a population‐based studyEuropean Journal of Neurology, 2009
- Neuroanatomical correlates of impaired decision‐making and facial emotion recognition in early Parkinson’s diseaseEuropean Journal of Neuroscience, 2009
- Cognitive decline in Parkinson’s disease: A prospective longitudinal studyJournal of the International Neuropsychological Society, 2009
- Cognitive impairment in incident, untreated Parkinson diseaseNeurology, 2009
- Evolution of cognitive dysfunction in an incident Parkinson's disease cohortBrain, 2007
- Cognitive profile of patients with newly diagnosed Parkinson diseaseNeurology, 2005
- The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN studyBrain, 2004
- Staging of brain pathology related to sporadic Parkinson’s diseaseNeurobiology of Aging, 2003