High protein intake is associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study
Open Access
- 19 December 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nutrition Journal
- Vol. 12 (1), 164
- https://doi.org/10.1186/1475-2891-12-164
Abstract
Protein intake has been inversely associated with frailty. However, no study has examined the effect of the difference of protein sources (animal or plant) or the amino acid composing the protein on frailty. Therefore, we examined the association of protein and amino acid intakes with frailty among elderly Japanese women. A total of 2108 grandmothers or acquaintances of dietetic students aged 65 years and older participated in this cross-sectional multicenter study, which was conducted in 85 dietetic schools in 35 prefectures of Japan. Intakes of total, animal, and plant protein and eight selected amino acids were estimated from a validated brief-type self-administered diet history questionnaire and amino acid composition database. Frailty was defined as the presence of three or more of the following four components: slowness and weakness (two points), exhaustion, low physical activity, and unintentional weight loss. The number of subjects with frailty was 481 (23%). Adjusted ORs (95% CI) for frailty in the first, second, third, fourth, and fifth quintiles of total protein intake were 1.00 (reference), 1.02 (0.72, 1.45), 0.64 (0.45, 0.93), 0.62 (0.43, 0.90), and 0.66 (0.46, 0.96), respectively (P for trend = 0.001). Subjects categorized to the third, fourth, and fifth quintiles of total protein intake (>69.8 g/d) showed significantly lower ORs than those to the first quintile (all P P for trend <0.04), with the multivariate adjusted OR in the highest compared to the lowest quintile of 0.73 for animal protein and 0.66 for plant protein, and 0.67-0.74 for amino acids, albeit that the ORs for these dietary variables were less marked than those for total protein. Total protein intake was significantly inversely associated with frailty in elderly Japanese women. The association of total protein with frailty may be observed regardless of the source of protein and the amino acid composing the protein.Keywords
This publication has 26 references indexed in Scilit:
- Distribution but not amount of protein intake is associated with frailty: a cross-sectional investigation in the region of NürnbergNutrition Journal, 2013
- A pilot randomized controlled trial to improve geriatric frailtyBMC Geriatrics, 2012
- Both Comprehensive and Brief Self-Administered Diet History Questionnaires Satisfactorily Rank Nutrient Intakes in Japanese AdultsJournal of Epidemiology, 2012
- Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on AgingAGE, 2011
- Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adultsPublic Health Nutrition, 2011
- Frailty and muscle metabolism dysregulation in the elderlyBiogerontology, 2010
- Protein Intake and Incident Frailty in the Women's Health Initiative Observational StudyJournal of the American Geriatrics Society, 2010
- Dietary protein recommendations and the prevention of sarcopeniaCurrent Opinion in Clinical Nutrition and Metabolic Care, 2009
- Validity of the Center for Epidemiologic Studies Depression Scale as a screening instrument of major depressive disorder among Japanese workersAmerican Journal of Industrial Medicine, 2006
- The CES-D ScaleApplied Psychological Measurement, 1977