Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes
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Open Access
- 25 January 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 13 (2), 118-132
- https://doi.org/10.1038/nri3383
Abstract
Marginal zone B cells are strategically positioned at the interface between the circulation and the white pulp of the spleen, where they can mediate a rapid, innate-like humoral response against both pathogens and commensals that breach the mucosal barrier. Understanding the interplay of these cells with other immune components and the species-specific differences between mice and humans is of clinical importance. Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the circulation and lymphoid tissue, splenic marginal zone B cells rapidly respond to blood-borne antigens by adopting 'crossover' defensive strategies that blur the conventional boundaries of innate and adaptive immunity. This Review discusses how marginal zone B cells function as innate-like lymphocytes that mount rapid antibody responses to both T cell-dependent and T cell-independent antigens. These responses require the integration of activation signals from germline-encoded and somatically recombined receptors for microorganisms with helper signals from effector cells of the innate and adaptive immune systems.Keywords
This publication has 133 references indexed in Scilit:
- Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12Immunity, 2009
- The Lymphotoxin LTα1β2 Controls Postnatal and Adult Spleen Marginal Sinus Vascular Structure and FunctionImmunity, 2009
- Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cellsEuropean Journal of Immunology, 2008
- IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in HumansImmunity, 2008
- Lymphotoxin-Mediated Crosstalk between B Cells and Splenic Stroma Promotes the Initial Type I Interferon Response to CytomegalovirusCell Host & Microbe, 2008
- Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiationJournal of Allergy and Clinical Immunology, 2007
- The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitantsHistochemistry and Cell Biology, 2006
- An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune SystemCell, 2005
- Blood Dendritic Cells Interact with Splenic Marginal Zone B Cells to Initiate T-Independent Immune ResponsesImmunity, 2002
- Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migrationNature, 2001