Mapping Drug Dose Distribution on CT Images Following Transarterial Chemoembolization with Radiopaque Drug-Eluting Beads in a Rabbit Tumor Model
- 1 November 2018
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 289 (2), 396-404
- https://doi.org/10.1148/radiol.2018172571
Abstract
Purpose To correlate bead location and attenuation on CT images with the quantity and distribution of drug delivered to the liver following transarterial chemoembolization (TACE) with radiopaque drug-eluting beads (DEB) in a rabbit tumor model. Materials and Methods All procedures were performed with a protocol approved by the Institutional Animal Care and Use Committee. TACE was performed in rabbits (n = 4) bearing VX2 liver tumors by using radiopaque DEB (70–150 µm) loaded with doxorubicin (DOX). Livers were resected 1 hour after embolization, immediately frozen, and cut by using liver-specific three-dimensional–printed molds for colocalization of liver specimens and CT imaging. DOX penetration into tissue surrounding beads was evaluated with fluorescence microscopy. DOX levels in liver specimens were predicted by using statistical models correlating DOX content measured in tissue with bead volume and attenuation measured on CT images. Model predictions were then compared with actual measured DOX concentrations to assess the models’ predictive power. Results Eluted DOX remained in close proximity (<600 µm) to beads in the liver 1 hour after TACE. Bead volume and attenuation measured on CT images demonstrated positive linear correlations (0.950 and 0.965, respectively) with DOX content in liver specimens. DOX content model predictions based on CT images were accurate compared with actual liver DOX levels at 1 hour. Conclusion CT may be used to estimate drug dose delivery and distribution in the liver following transarterial chemoembolization (TACE) with doxorubicin-loaded radiopaque drug-eluting beads (DEB). Although speculative, this informational map might be helpful in planning and understanding the spatial effects of TACE with DEB. © RSNA, 2018Funding Information
- National Institutes of Health
This publication has 35 references indexed in Scilit:
- Evaluation of HCC response to locoregional therapy: Validation of MRI-based response criteria versus explant pathologyJournal of Hepatology, 2017
- DC BeadM1™: towards an optimal transcatheter hepatic tumour therapyJournal of Materials Science: Materials in Medicine, 2015
- Feasibility, safety and pharmacokinetic study of hepatic administration of drug-eluting beads loaded with irinotecan (DEBIRI) followed by intravenous administration of irinotecan in a porcine modelJournal of Materials Science: Materials in Medicine, 2012
- Transcatheter Intraarterial Therapies: Rationale and OverviewRadiology, 2011
- Comparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancerJournal of Materials Science: Materials in Medicine, 2010
- Radiologic–Pathologic Correlation of Hepatocellular Carcinoma Treated with ChemoembolizationCardioVascular and Interventional Radiology, 2009
- Correlation of Multislice CT and Histomorphology in HCC Following TACE: Predictors of OutcomeCardioVascular and Interventional Radiology, 2008
- A Phase I/II Trial of Chemoembolization for Hepatocellular Carcinoma Using a Novel Intra-Arterial Drug-Eluting BeadClinical Gastroenterology and Hepatology, 2007
- Pharmacokinetic and Safety Study of Doxorubicin-eluting Beads in a Porcine Model of Hepatic Arterial EmbolizationJournal of Vascular and Interventional Radiology, 2006
- Liver and tumor uptake and plasma pharmacokinetic of arterial cisplatin administered with and without starch microspheres in patients with liver metastasesCancer, 1991