Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil.
- 1 March 1983
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 67 (3), 504-511
- https://doi.org/10.1161/01.cir.67.3.504
Abstract
Epidemiologic and experimental data suggest an antiatherothrombotic potential of omega-3 polyunsaturated fatty acids. Therefore, the Western diet, which supplies predominantly omega-6 polyunsaturated fatty acids, was supplemented with 40 ml/day of cod liver oil, which provides about 10 g of omega-3 polyunsaturated fatty acids daily, for 25 days in eight volunteers. The omega-3 polyunsaturated fatty acids were incorporated in platelet and erythrocyte membrane phospholipids at the expense of omega-6 polyunsaturated fatty acids. Bleeding time increased (p less than 0.01) and platelet count (p less than 0.05), platelet aggregation upon ADP and collagen (p less than 0.01-0.05), and associated thromboxane B2 formation (p less than 0.01) decreased. Blood pressure (p less than 0.05) and blood pressure response to norepinephrine (p less than 0.01) and angiotensin II (NS) fell, without major changes in plasma catecholamines, renin, urinary aldosterone, kallikrein, prostaglandins E2 and F2 alpha and red cell cation fluxes. Biochemical and functional changes were reversed 4 weeks after cod liver oil was discontinued. Formation of prostaglandins derived from eicosapentaenoic acid and interference of eicosapentaenoic acid with formation and action of prostaglandins derived from arachidonic acid were evident in vitro. Whatever the mechanism, this moderate supplement of omega-3 polyunsaturated fatty acids markedly changed membrane phospholipids, which was associated with a shift toward less reactive platelets and a blunted circulatory response to pressure hormones.Keywords
This publication has 47 references indexed in Scilit:
- Sodium-lithium exchange and sodium-potassium cotransport in human erythrocytes. Part 2: A simple uptake test applied to normotensive and essential hypertensive individuals.Hypertension, 1982
- Transformations of 5,8,11,14,17-eicosapentaenoic acid in human plateletsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
- Increased Sodium-Lithium Countertransport in Red Cells of Patients with Essential HypertensionNew England Journal of Medicine, 1980
- Laboratory Distinction between Essential and Secondary Hypertension by Measurement of Erythrocyte Cation FluxesNew England Journal of Medicine, 1980
- Inhibition of prostaglandin biosynthesis by eicosapentaenoic acidProstaglandins and Medicine, 1979
- The protective effects of dietary fish oil on focal cerebral infarctionProstaglandins and Medicine, 1979
- Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel WallsNew England Journal of Medicine, 1979
- Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamineLife Sciences, 1977
- Radioimmunoassay of free aldosterone and of its 18-oxo-glucuronide in human urineCellular and Molecular Life Sciences, 1972
- Incorporation of fatty acids of marine origin into triglycerides and phospholipids of mammalsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967