Discontinuation and reinitiation patterns of osteoporosis treatment among commercially insured postmenopausal women
Open Access
- 1 November 2013
- journal article
- Published by Taylor & Francis Ltd in International Journal of General Medicine
- Vol. 6, 839-848
- https://doi.org/10.2147/IJGM.S36944
Abstract
Discontinuation and reinitiation patterns of osteoporosis treatment among commercially insured postmenopausal women Akhila Balasubramanian,1 M Alan Brookhart,2 Vamshidar Goli1 Cathy W Critchlow1 1Amgen Inc, Thousand Oaks, CA, USA; 2University of North Carolina at Chapel Hill, Chapel Hill, NC, USAObjective: Poor adherence to chronic medications is common and compromises medication effectiveness. We sought to describe longitudinal patterns of osteoporosis medication use.Study design: This was a retrospective observational cohort study using 2005–2009 data from a large, commercially insured population.Methods: Patients were women aged ≥55 years initiating osteoporosis therapy who had a ≥12-month (baseline) period with no osteoporosis therapy claims preceding initiation, and ≥24 months follow-up after therapy initiation. Discontinuation was defined as a gap >60 days (varied in sensitivity analyses) in prescription claims. Reinitiation was defined as a prescription claim for the same or different osteoporosis therapy following the therapy gap. Discontinuation and reinitiation patterns were described using Kaplan–Meier analysis. Multivariable Cox regression assessed the impact of baseline factors on reinitiation.Results: Of the 92,839 patients, 45%, 58%, and 70% discontinued therapy at 6, 12, and 24 months, respectively, following initiation. Of the discontinuers, 46% reinitiated therapy, with the majority doing so within 6 months of discontinuation. Women were less likely to reinitiate therapy if they were older (P < 0.0001) or were hospitalized during baseline (P = 0.0007). Women who discontinued treatment early (<6 months) following initiation were less likely to reinitiate (P < 0.0001) and remained on therapy for shorter periods following reinitiation. Depending on the available observation time, the median time on therapy following reinitiation was 58–193 days. Study findings did not change appreciably in sensitivity analyses.Conclusion: Many patients stop and restart treatment for osteoporosis. A better understanding of determinants of treatment stopping and restarting could inform adherence improvement efforts. Keywords: bisphosphonates, persistence, adherence, osteoporosis, therapy utilizationKeywords
This publication has 29 references indexed in Scilit:
- Perspectives on pre-fracture intervention strategies: the Geisinger Health System Osteoporosis ProgramOsteoporosis International, 2011
- Bisphosphonate prescribing, persistence and cumulative exposure in Ontario, CanadaOsteoporosis International, 2011
- American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Postmenopausal OsteoporosisEndocrine Practice, 2010
- Excess mortality following hip fracture: the role of underlying health statusOsteoporosis International, 2007
- The impact of osteoporosis medication beliefs and side-effect experiences on non-adherence to oral bisphosphonatesCurrent Medical Research and Opinion, 2007
- The effect of dosing frequency on compliance and persistence with bisphosphonate therapy in postmenopausal women: A comparison of studies in the United States, the United Kingdom, and FranceClinical Therapeutics, 2006
- Medication Persistence With Weekly Versus Daily Doses of Orally Administered BisphosphonatesEndocrine Practice, 2006
- Compliance With Osteoporosis MedicationsArchives of Internal Medicine, 2005
- Functional outcome and quality of life following hip fracture in elderly women: a prospective controlled studyOsteoporosis International, 2003
- Early discontinuation of treatment for osteoporosisAmerican Journal Of Medicine, 2003