Organizational principles of 3D genome architecture
Top Cited Papers
- 26 October 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 19 (12), 789-800
- https://doi.org/10.1038/s41576-018-0060-8
Abstract
Studies of 3D chromatin organization have suggested that chromosomes are hierarchically organized into large compartments composed of smaller domains called topologically associating domains (TADs). Recent evidence suggests that compartments are smaller than previously thought and that the transcriptional or chromatin state is responsible for interactions leading to the formation of small compartmental domains in all organisms. In vertebrates, CTCF forms loop domains, probably via an extrusion process involving cohesin. CTCF loops cooperate with compartmental domains to establish the 3D organization of the genome. The continuous extrusion of the chromatin fibre by cohesin may also be responsible for the establishment of enhancer–promoter interactions and stochastic aspects of the transcription process. These observations suggest that the 3D organization of the genome is an emergent property of chromatin and its components, and thus may not be only a determinant but also a consequence of its function.Keywords
This publication has 97 references indexed in Scilit:
- Self-organization of domain structures by DNA-loop-extruding enzymesNucleic Acids Research, 2012
- Loss of Maternal CTCF Is Associated with Peri-Implantation Lethality of Ctcf Null EmbryosPLOS ONE, 2012
- Topological domains in mammalian genomes identified by analysis of chromatin interactionsNature, 2012
- Spatial partitioning of the regulatory landscape of the X-inactivation centreNature, 2012
- Inhibiting eukaryotic transcription. Which compound to choose? How to evaluate its activity?Transcription, 2011
- Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human GenomeScience, 2009
- Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo developmentDevelopment, 2008
- The Insulator Binding Protein CTCF Positions 20 Nucleosomes around Its Binding Sites across the Human GenomePLoS Genetics, 2008
- Transcription Alters Chromosomal Locations of Cohesin in Saccharomyces cerevisiaeMolecular and Cellular Biology, 2007
- Disseminating the Genome: Joining, Resolving, and Separating Sister Chromatids During Mitosis and MeiosisAnnual Review of Genetics, 2001