Development of Novel Interpenetrating Network Gellan Gum-Poly(vinyl alcohol) Hydrogel Microspheres for the Controlled Release of Carvedilol
- 1 January 2005
- journal article
- research article
- Published by Taylor & Francis Ltd in Drug Development and Industrial Pharmacy
- Vol. 31 (6), 491-503
- https://doi.org/10.1080/03639040500215875
Abstract
Novel interpenetrating polymeric network microspheres of gellan gum and poly(vinyl alcohol) were prepared by the emulsion cross-linking method. Carvedilol, an antihypertensive drug, was successfully loaded into these microspheres prepared by changing the experimental variables such as ratio of gellan gum:poly(vinyl alcohol) and extent of cross-linking in order to optimize the process variables on drug encapsulation efficiency, release rates, size, and morphology of the microspheres. Formation of interpenetrating network and the chemical stability of carvedilol after preparing the microspheres was confirmed by Fourier transform infrared spectroscopy. Differential scanning calorimetry and x-ray diffraction studies were made on the drug-loaded microspheres to investigate the crystalline nature of the drug after encapsulation. Results indicated a crystalline dispersion of carvedilol in the polymer matrix. Scanning electron microscopy confirmed the spherical nature and smooth surface morphology of the microspheres produced. Mean particle size of the microspheres as measured by laser light scattering technique ranged between 230 and 346 microm. Carvedilol was successfully encapsulated up to 87% in the polymeric matrices. In vitro release studies were performed in the simulated gastric fluid or simulated intestinal fluid. The release of carvedilol was continued up to 12 h. Dynamic swelling studies were performed in the simulated gastric fluid or simulated intestinal fluid, and diffusion coefficients were calculated by considering the spherical geometry of the matrices. The release data were fitted to an empirical relation to estimate the transport parameters. The mechanical properties of interpenetrating polymeric networks prepared were investigated. Network parameters such as molar mass between cross-links and cross-linking density for interpenetrating polymeric networks were calculated.Keywords
This publication has 23 references indexed in Scilit:
- Formulation and evaluation of novel tableted chitosan microparticles for the controlled release of clozapineJournal of Microencapsulation, 2004
- Controlled release of clozapine through chitosan microparticles prepared by a novel methodJournal of Controlled Release, 2004
- Sustained release of acetaminophen from a heterogeneous mixture of two hydrophilic non-ionic cellulose ether polymersInternational Journal of Pharmaceutics, 2004
- Release kinetics and diffusion coefficients of solid and liquid pesticides through interpenetrating polymer network beads of polyacrylamide-g-guar gum with sodium alginateJournal of Applied Polymer Science, 2003
- Changes in Cisplatin Delivery Due to Surface-Coated Poly (Lactic Acid)–Poly(∊-Caprolactone)MicrospheresJournal of Biomaterials Applications, 2002
- Lignin-poly (vinyl alcohol) blends studied by thermal analysisPolymer Degradation and Stability, 1999
- Identification and location of l-glycerate, an unusual acyl substituent in gellan gumCarbohydrate Research, 1986
- Structural studies of gellan gum, an extracellular polysaccharide elaborated by Pseudomonas elodeaCarbohydrate Research, 1983
- Controlled Release: Mechanisms and RatesPublished by Springer Science and Business Media LLC ,1974
- Cohesive energy densities of polymers. Part 1.—Cohesive energy densities of rubbers by swelling measurementsTransactions of the Faraday Society, 1958