Epstein-Barr Virus, Cytomegalovirus, and Other Viral Infections in Children After Liver Transplantatlon
- 1 August 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 156 (2), 273-279
- https://doi.org/10.1093/infdis/156.2.273
Abstract
We studied 51 consecutive pediatric patients for the frequency and morbidity of viral infections after liver transplantation. The incidence of primary (67%) and reactivation (48%) Epstein-Barr virus (EBV) infections and reactivation (88%) cytomegalovirus (CMV) infection was comparable to that seen in adult transplant recipients. However, fewer pediatric than adult transplant recipients experienced primary CMV infection (P < .01). Five (38%) of 13CMV infections were symptomatic and included hepatitis, pneumonitis, enteritis, and mononucleosis. Tho of 14 patients with primary EBV infection subsequently developed, at two months and two years after initial infection, an EBV-associated lymphoproliferative syndrome, and one of 10 patients with reactivated EBV infection developed a possible EBV-associated febrile encephalopathy. Other viruses causing infection in these children included herpes simplex virus, varicella-zoster virus, adenovirus, parainfluenza virus, respiratory syncytial virus, and rotavirus.Keywords
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