Antibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
Open Access
- 15 July 2009
- journal article
- research article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 75 (14), 4919-4922
- https://doi.org/10.1128/aem.00681-09
Abstract
Certain streptomycin resistance mutations (i.e., rpsL and rsmG ) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea , accompanied by increased transcription of a key developmental regulator gene, bldD , in the latter organism.Keywords
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