Lymphocytic esophagitis: an update on histologic diagnosis, endoscopic findings, and natural history
- 24 May 2018
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1434 (1), 185-191
- https://doi.org/10.1111/nyas.13710
Abstract
Lymphocytic esophagitis is a histologic pattern of injury characterized by increased intraepithelial lymphocytes (>20/high‐power field) with rare, or absent granulocytes. Lymphocytes tend to be more numerous in the peripapillary epithelium, and are often associated with evidence of mucosal injury, edema, and scattered dyskeratotic cells. More than a decade following its original description, lymphocytic esophagitis remains an enigmatic entity with variable clinical presentations, associated disorders, etiologies, treatment, and natural history. Most of the confusion regarding the clinical significance of this disorder stems from its diagnostic criteria: lymphocytic esophagitis is currently defined based entirely on histologic criteria, despite the common occurrence of lymphocytosis in a variety of unrelated inflammatory conditions of the esophagus. The goal of this review is to summarize the literature regarding lymphocytic esophagitis and focus on key clinicopathologic features that distinguish it from other esophageal disorders that can show increased numbers of intraepithelial lymphocytes.Keywords
This publication has 28 references indexed in Scilit:
- Unusual Cause for Smoldering DysphagiaDysphagia, 2013
- Lymphocytic EsophagitisJournal of Clinical Gastroenterology, 2012
- The Prevalence and Diagnostic Utility of Endoscopic Features of Eosinophilic Esophagitis: A Meta-analysisClinical Gastroenterology and Hepatology, 2012
- Lymphocytic oesophagitis: clinicopathological aspects of an emerging conditionGut, 2011
- Lymphocytic Esophagitis Presenting as Chronic DysphagiaClinical Medicine & Research, 2011
- Budesonide Is Effective in Adolescent and Adult Patients With Active Eosinophilic EsophagitisGastroenterology, 2010
- Redefining the role of lymphocytes in gastroesophageal reflux disease and eosinophilic esophagitisDiseases of the Esophagus, 2010
- Lymphocytic EsophagitisAmerican Journal of Clinical Pathology, 2008
- Lymphocytic EsophagitisAmerican Journal of Clinical Pathology, 2006
- AchalasiaThe American Journal of Surgical Pathology, 1994