Determination of Clarithromycin as a Contaminant on Surfaces by High-Performance Liquid Chromatography Using Electrochemical Detection

Abstract

Microgram levels of clarithromycin residues on various surfaces are quantitated. After cleaning, any residual clarithromycin remaining is removed from the surface by a wet swab–dry swab technique. High-performance liquid chromatography with electrochemical detection is used for quantitation of the resulting solutions. Recoveries ranged from 93 to 118%.