Duloxetine
- 1 May 2010
- journal article
- review article
- Published by BMJ in Regional Anesthesia & Pain Medicine
- Vol. 35 (3), 294-303
- https://doi.org/10.1097/aap.0b013e3181df2645
Abstract
Duloxetine is a serotonin and norepinephrine reuptake inhibitor that possesses antidepressant and pain-relieving properties. Compared with other antidepressants, it has a high affinity for both norepinephrine and serotonin reuptake transporters, which are relatively balanced. Analgesic onset has been observed within the first week of administration in randomized controlled trials and is likely obtained by enhancing the tone of the descending pain inhibition pathways of the central nervous system. Randomized trials have documented significant analgesic effects for managing chronic pain associated with fibromyalgia and diabetic peripheral neuropathic pain. Studies have also suggested that pain associated with major depressive disorder can be reduced with this medication. Modest effects for headache, osteoarthritic pain, and pain secondary to Parkinson disease have also been documented, but data are obtained from single-blinded or open-label trials that require further corroboration with larger randomized studies. Duloxetine has not yet been directly compared with other antidepressants or anticonvulsants for the treatment of pain syndromes.Keywords
This publication has 69 references indexed in Scilit:
- Meta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic painBMC Neurology, 2009
- Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trialsBMC Neurology, 2008
- In Vitro and In Vivo Evaluations of Cytochrome P450 1A2 Interactions with DuloxetineClinical Pharmacokinetics, 2008
- A Comparison of Initial Duloxetine Dosing Strategies in Patients With Major Depressive DisorderThe Journal of Clinical Psychiatry, 2007
- Duloxetine vs. placebo in patients with painful diabetic neuropathyPain, 2005
- Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic painNeuropharmacology, 2004
- Efficacy of Duloxetine, a Potent and Balanced Serotonergic and Noradrenergic Reuptake Inhibitor, in Inflammatory and Acute Pain Models in RodentsJournal of Pharmacology and Experimental Therapeutics, 2004
- Serotonin and noradrenaline reuptake inhibitors in animal models of painHuman Psychopharmacology: Clinical and Experimental, 2004
- A double‐blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorderArthritis & Rheumatism, 2004
- Descending control of painProgress in Neurobiology, 2002