Insulin‐like growth factors and pancreas beta cells
- 13 April 2004
- journal article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 34 (4), 249-255
- https://doi.org/10.1111/j.1365-2362.2004.01337.x
Abstract
Insulin-like growth factors (IGFs) have been implicated in normal growth, and especially foetal pancreas beta-cell development. As low birth weight has been implicated in the development of obesity and type 2 diabetes, much research has evolved into the importance of IGF and their signalling pathways for pancreas beta-cell development, and for type 2 diabetes. Insulin-like growth factor-I signalling has a lot in common with insulin signalling, and is involved in diverse cellular effects such as antiapoptosis, protein synthesis, cell growth and mitogenesis. Insulin-like growth factor-II can be bound by the insulin receptor A subtype and the IGF-1 receptor, which may explain its antiapoptotic effect. Various knock-out model studies indicate that absence of IGF-I or the IGF-1 receptor is critical for foetal and postnatal growth. Similarly, knock-out models of post-receptor molecules (such as IRS-2) point to the physiological role of IGFs for pancreas beta-cell development. A beta-cell-specific IGF-1 receptor knock out model indicates the importance of IGF-I for beta-cell function. The Goto-Kakizaki (GK) rat, a model for diabetes, has insufficient beta-cell development, which may be related to its defective IGF-II synthesis. As normal pancreas beta cells adapt to the prevailing insulin resistance with increasing beta-cell function, it is possible that insulin resistance interacts with IGF signalling in pancreas beta cells.Keywords
This publication has 68 references indexed in Scilit:
- Progenitor cells in the adult pancreasDiabetes/Metabolism Research and Reviews, 2004
- Gene regulatory factors in pancreatic developmentDevelopmental Dynamics, 2003
- IRS-3 inhibits IRS-2-mediated signaling in pancreatic β-cellsMolecular and Cellular Endocrinology, 2003
- Insulin-like growth factor-1 downregulates nuclear factor κB activation and upregulates interleukin-8 gene expression induced by tumor necrosis factor αBiochemical and Biophysical Research Communications, 2003
- Pancreatic β-cell growth and survival – a role in obesity-linked type 2 diabetes?Trends in Molecular Medicine, 2002
- Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational studyThe Lancet, 2002
- Insulin‐like growth factor‐1 protects peroxynitrite‐induced cell death by preventing cytochromec‐induced caspase‐3 activationJournal of Cellular Biochemistry, 2002
- Differential Activation of Protein Kinase B and p70S6K by Glucose and Insulin-like Growth Factor 1 in Pancreatic β-Cells (INS-1)Published by Elsevier BV ,2001
- Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic -Cell Line INS-1Endocrinology, 2001
- The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitusJCI Insight, 1999