Birth Prevalence and Natural History of Congenital Cytomegalovirus Infection in a Highly Seroimmune Population
Open Access
- 15 August 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 49 (4), 522-528
- https://doi.org/10.1086/600882
Abstract
Background. The natural history of congenital cytomegalovirus (CMV) infection is scarcely known in populations with high maternal CMV seroprevalence. This study evaluated the birth prevalence, clinical findings at birth, and hearing outcome in CMV-infected children from such a population. Methods. Consecutively born infants were screened for the presence of CMV in urine and/or saliva specimens during the first 2 weeks after birth. Neonatal clinical findings were recorded, and CMV-infected children were tested to document hearing function during follow-up. A subset of mothers of CMV-infected infants were prenatally tested for the presence of anti-CMV immunoglobulin G antibodies. Results. Congenital CMV infection was confirmed in 87 (1.08%; 95% confidence interval [CI], 0.86%-1.33%) of 8047 infants. Seven infants (8.1%; 95% CI, 3.3%-15.9%) had at least 1 clinical finding suggestive of CMV infection, and 4 (4.6%; 95% CI, 1.3%-11.3%) had >3 findings of systemic disease. Sensorineural hearing loss was found in 5 (8.6%; 95% CI, 2.9%-19.0%) of 58 children tested at a median age of 21 months. Bilateral profound hearing loss was observed in 2 children, and the hearing threshold was >60 decibels in all 5 children with hearing loss, including 2 children born to mothers with probable nonprimary CMV infection. Conclusions. The results of this large newborn screening study in a population with high CMV seroimmunity provide additional evidence that congenital CMV disease occurs in populations with high seroprevalence rates, with a similar incidence of CMV-related hearing loss to that reported in the offspring of women from populations in developed countries with lower rates of seroimmunity to CMV.Keywords
This publication has 47 references indexed in Scilit:
- CONGENITAL CYTOMEGALOVIRUS INFECTION IN A HIGHLY SEROPOSITIVE SEMI-URBAN POPULATION IN INDIAThe Pediatric Infectious Disease Journal, 2008
- Primary versus Nonprimary Cytomegalovirus Infection during Pregnancy, IsraelEmerging Infectious Diseases, 2007
- Review and meta‐analysis of the epidemiology of congenital cytomegalovirus (CMV) infectionReviews in Medical Virology, 2007
- Is saliva as reliable as urine for detection of cytomegalovirus DNA for neonatal screening of congenital CMV infection?Journal of Clinical Virology, 2006
- Clinical findings and adverse outcome in neonates with symptomatic congenital cytomegalovirus (SCCMV) infectionEuropean Journal of Pediatrics, 2006
- Congenital cytomegalovirus infection in preterm and full-term newborn infants from a population with a high seroprevalence rateThe Pediatric Infectious Disease Journal, 2001
- Human Cytomegalovirus Infection of Placental Cytotrophoblasts In Vitro and In Utero: Implications for Transmission and PathogenesisJournal of Virology, 2000
- Longitudinal Investigation of Hearing Disorders in Children with Congenital CytomegalovirusJournal of the American Academy of Audiology, 2000
- Combination of microneutralization and avidity assays: Improved diagnosis of recent primary human cytomegalovirus infection in single serum sample of second trimester pregnancyJournal of Medical Virology, 2000
- Report on a Long-term Study of Maternal and Congenital Cytomegalovirus Infection in Sweden. Review of Prospective Studies Available in the LiteratureScandinavian Journal of Infectious Diseases, 1999